Peptipedia
HormonalFDA ApprovedFDA Approved

Abaloparatide

Also known as Tymlos, BA058

A PTHrP analog that stimulates bone formation with potentially fewer side effects than teriparatide. Represents a newer anabolic option for osteoporosis management.

FDA Approved - Postmenopausal osteoporosis
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

80 mcg daily

Frequency

Once daily

Duration

Maximum 2 years (lifetime limit)

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 80 mcg daily via Subcutaneous injection, Once daily. Dose range: 80 mcg daily. Duration: Maximum 2 years (lifetime limit).

Timing & Administration

Administer via Subcutaneous injection. Frequency: Once daily.

Mechanism of Action

Analog of PTH-related protein (PTHrP). Preferentially binds to the RG conformation of PTH1 receptor, favoring anabolic signaling over bone resorption.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Postmenopausal osteoporosis.

Side Effects & Safety

Important Warnings

  • Osteosarcoma risk in rats
  • Maximum 2-year lifetime treatment.
Hypercalciuria (11%)
dizziness (10%)
nausea (8%)
palpitations (5%)
injection site reactions
orthostatic hypotension

References

No references available.

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