Peptipedia
HormonalFDA ApprovedFDA Approved

Bivalirudin

Also known as Angiomax, Angiox

A synthetic direct thrombin inhibitor derived from hirudin used as an anticoagulant during percutaneous coronary intervention procedures.

FDA Approved - PCI anticoagulation
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

0.75 mg/kg IV bolus; 1.75 mg/kg/h infusion

Frequency

IV bolus + infusion during procedure

Duration

Duration of procedure

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 0.75 mg/kg IV bolus; 1.75 mg/kg/h infusion via IV bolus and infusion, IV bolus + infusion during procedure. Dose range: 0.75 mg/kg bolus; 1.75 mg/kg/h infusion. Duration: Duration of procedure.

Timing & Administration

Administer via IV bolus and infusion. Frequency: IV bolus + infusion during procedure.

Mechanism of Action

Directly inhibits thrombin by binding to both its active site and exosite 1. Unlike heparin, it inhibits both free and clot-bound thrombin.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - PCI anticoagulation.

Side Effects & Safety

Important Warnings

  • Acute stent thrombosis risk
Bleeding (28%)
headache
thrombocytopenia
hypotension
acute stent thrombosis
allergic reactions

References

No references available.

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