Peptipedia
HormonalFDA ApprovedFDA Approved

Desmopressin

Also known as DDAVP, Stimate, Minirin

Synthetic vasopressin analog that selectively activates V2 receptors in kidneys, promoting water reabsorption.

FDA Approved - Multiple indications (first approved 1978)
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

10-40 mcg intranasal or 0.1-0.4 mg oral

Frequency

Per indication

Duration

Varies by condition

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 10-40 mcg intranasal or 0.1-0.4 mg oral via Intranasal, oral, IV, or subcutaneous, Per indication. Dose range: 10-40 mcg intranasal; 0.1-0.4 mg oral. Duration: Varies by condition.

Timing & Administration

Administer via Intranasal, oral, IV, or subcutaneous. Frequency: Per indication.

Mechanism of Action

Selectively activates V2 receptors in kidneys, promoting water reabsorption without affecting V1 receptors. Also releases von Willebrand factor and Factor VIII for hemostasis.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Multiple indications (first approved 1978).

Side Effects & Safety

Important Warnings

  • Hyponatremia risk - seizure potential with water intoxication
Headache (common)
hyponatremia (major risk)
water intoxication
nausea
nasal congestion
thrombotic events (rare)

References

No references available.

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