CognitivePreclinicalAnimal Studies

Dihexa

Also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

A potent cognitive-enhancing peptide derived from angiotensin IV. Reported to be 10 million times more potent than BDNF at promoting synaptogenesis.

Preclinical - Research compound

Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

5-20 mg oral or sublingual daily

Frequency

Once daily

Duration

Cycles of 2-4 weeks

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 5-20 mg oral or sublingual daily via Oral, sublingual, or intranasal, Once daily. Dose range: 5-40 mg daily. Duration: Cycles of 2-4 weeks.

Timing & Administration

Administer via Oral, sublingual, or intranasal. Frequency: Once daily.

Mechanism of Action

Activates hepatocyte growth factor signaling via the c-Met receptor, promoting dendritic spine formation, enhancing synaptic connections, and supporting neuronal survival. Crosses the blood-brain barrier.

Research Summary

Evidence level: animal studies. Clinical status: Preclinical - Research compound.

Side Effects & Safety

Important Warnings

  • Activates c-Met pathway which may promote cancer cell growth - avoid if history of cancer
  • No human clinical trials conducted.
Nervousness
headache
anxiety
insomnia
nausea
potential bleeding problems
concerns about tumor development

References

No references available.