Peptipedia
HormonalFDA ApprovedFDA Approved

Glucagon

Also known as GlucaGen, Baqsimi

Life-saving treatment for severe hypoglycemia since the 1960s. Newer formulations include nasal spray (Baqsimi) and stable liquid (Gvoke).

FDA Approved - Hypoglycemia and diagnostic
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

1 mg IM/SC/IV or 3 mg intranasal (Baqsimi)

Frequency

Single dose emergency use

Duration

Emergency single dose

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 1 mg IM/SC/IV or 3 mg intranasal (Baqsimi) via Injection, intranasal, or auto-injector, Single dose emergency use. Dose range: 1-3 mg per dose. Duration: Emergency single dose.

Timing & Administration

Administer via Injection, intranasal, or auto-injector. Frequency: Single dose emergency use.

Mechanism of Action

Binds to glucagon receptors in the liver, activating glycogenolysis and gluconeogenesis to raise blood glucose. Also relaxes smooth muscle in the GI tract for diagnostic imaging.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Hypoglycemia and diagnostic.

Side Effects & Safety

Important Warnings

  • Contraindicated with pheochromocytoma
Nausea (up to 35%)
vomiting
headache
hypertension
tachycardia
allergic reactions
rebound hypoglycemia

References

No references available.

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