Peptipedia
HormonalFDA ApprovedFDA Approved

Linaclotide

Also known as Linzess, Constella

A peptide activator of guanylate cyclase-C for irritable bowel syndrome with constipation and chronic idiopathic constipation, with localized gut action and minimal systemic uptake.

FDA Approved - IBS-C and chronic constipation
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

290 mcg daily (IBS-C) or 145 mcg daily (CIC)

Frequency

Daily

Duration

Long-term / chronic use

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 290 mcg daily (IBS-C) or 145 mcg daily (CIC) via Oral capsule on empty stomach, Daily. Dose range: 72-290 mcg daily. Duration: Long-term / chronic use.

Timing & Administration

Administer via Oral capsule on empty stomach. Frequency: Daily.

Mechanism of Action

Activates guanylate cyclase-C on intestinal epithelium, increasing cGMP which leads to chloride and water secretion into the intestines. Also reduces visceral pain signaling.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - IBS-C and chronic constipation.

Side Effects & Safety

Important Warnings

  • Contraindicated in children under 2 years
Diarrhea (up to 50%)
abdominal pain
flatulence
fecal incontinence

References

No references available.

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