Peptipedia
HormonalNot FDA ApprovedCommunity Reported

Melanotan II

Also known as MT-II, MT2, Melanotan 2

A synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). Known for inducing skin tanning and having effects on libido and sexual function.

Not approved - Research discontinued due to side effects
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

250-500 mcg daily (loading), 500-1,000 mcg weekly (maintenance)

Frequency

Daily during loading (1-2 weeks), then weekly maintenance

Duration

Loading 2-3 weeks, then maintenance

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 250-500 mcg daily (loading), 500-1,000 mcg weekly (maintenance) via Subcutaneous injection, Daily during loading (1-2 weeks), then weekly maintenance. Dose range: 100-1,000 mcg per dose. Duration: Loading 2-3 weeks, then maintenance.

Timing & Administration

Administer via Subcutaneous injection. Frequency: Daily during loading (1-2 weeks), then weekly maintenance.

Mechanism of Action

Binds to melanocortin receptors (MC1R for tanning, MC4R for sexual effects). MC1R activation stimulates melanin production. MC4R activation in the brain influences sexual arousal and erectile function.

Research Summary

Evidence level: community reported. Clinical status: Not approved - Research discontinued due to side effects.

Side Effects & Safety

Important Warnings

  • Illegal status in US, UK, Australia
  • Priapism is a medical emergency
  • Melanoma risk.
Nausea
facial flushing
fatigue
spontaneous erections
skin and mole darkening
priapism
melanoma risk association
histamine release

References

No references available.

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