Peptipedia
HormonalFDA ApprovedFDA Approved

Octreotide

Also known as Sandostatin, Octreotide LAR

A somatostatin analog that binds to SST2 and SST5 receptors, suppressing GH, glucagon, insulin, and gastrointestinal hormones.

FDA Approved - Multiple indications
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

100-500 mcg SC 2-3x daily or LAR monthly

Frequency

2-3x daily (SC) or monthly (LAR)

Duration

Long-term / chronic use

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 100-500 mcg SC 2-3x daily or LAR monthly via Subcutaneous or intramuscular depot, 2-3x daily (SC) or monthly (LAR). Dose range: 100-500 mcg per dose (SC) or monthly LAR. Duration: Long-term / chronic use.

Timing & Administration

Administer via Subcutaneous or intramuscular depot. Frequency: 2-3x daily (SC) or monthly (LAR).

Mechanism of Action

Binds to somatostatin receptors (SST2 and SST5), suppressing release of growth hormone, glucagon, insulin, and GI hormones while reducing GI motility and demonstrating antitumor effects on neuroendocrine tumors.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - Multiple indications.

Side Effects & Safety

Important Warnings

  • High gallstone incidence with long-term use
Nausea
diarrhea
abdominal pain
gallstones (52-63% long-term)
bradycardia
hyperglycemia or hypoglycemia
hypothyroidism
pancreatitis

References

No references available.

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