Peptipedia
HormonalFDA ApprovedFDA Approved

Plecanatide

Also known as Trulance

A uroguanylin analog for chronic constipation and IBS-C, engineered to mimic a naturally occurring peptide. pH-sensitive activation may provide more targeted action in the small intestine.

FDA Approved - CIC and IBS-C
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

3 mg once daily

Frequency

Daily

Duration

Long-term / chronic use

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 3 mg once daily via Oral tablet with or without food, Daily. Dose range: 3 mg daily. Duration: Long-term / chronic use.

Timing & Administration

Administer via Oral tablet with or without food. Frequency: Daily.

Mechanism of Action

Structurally similar to human uroguanylin and activates guanylate cyclase-C. pH-sensitive activation may provide more targeted action in the small intestine.

Research Summary

Evidence level: fda approved. Clinical status: FDA Approved - CIC and IBS-C.

Side Effects & Safety

Important Warnings

  • Contraindicated in children under 6 years
Diarrhea (4-5%)
nausea

References

No references available.

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