Skin & HairNot FDA ApprovedClinical Trials

GHK-Cu

Also known as Copper Peptide, Glycyl-L-histidyl-L-lysine copper

A naturally occurring copper-binding peptide found in human plasma, saliva, and urine. Widely used in skincare for its wound healing and anti-aging properties.

Widely used in cosmetics - Human clinical studies support topical efficacy

Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

1-2 mg daily (injection) or 0.05% topical

Frequency

Once daily

Duration

Varies by application

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 1-2 mg daily (injection) or 0.05% topical via Subcutaneous injection or topical application, Once daily. Dose range: 1-2 mg daily. Duration: Varies by application.

Timing & Administration

Administer via Subcutaneous injection or topical application. Frequency: Once daily.

Mechanism of Action

Stimulates collagen and elastin synthesis, promotes glycosaminoglycan production, supports blood vessel growth, and has antioxidant and anti-inflammatory properties. Remodels damaged tissue and activates wound-healing genes.

Research Summary

Evidence level: clinical trials. Clinical status: Widely used in cosmetics - Human clinical studies support topical efficacy.

Side Effects & Safety

Important Warnings

  • Contraindicated with Wilson's disease
  • Caution with active cancer (angiogenesis concern).
Mild skin irritation (topical)
redness or tingling
injection site reactions
potential histamine release
risk of copper toxicity with excessive use

References

No references available.