Peptipedia
Skin & HairNot FDA ApprovedCommunity Reported

Matrixyl

Also known as Palmitoyl Pentapeptide-4, Pal-KTTKS

A lipopeptide that signals to fibroblasts to produce more collagen and other extracellular matrix proteins. Studies show significant reduction in wrinkle depth and volume.

Cosmetic use - Extensively studied
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

3-8% in formulations

Frequency

Applied twice daily

Duration

8-12 weeks for visible results, ongoing use

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 3-8% in formulations via Topical (serums, creams), Applied twice daily. Dose range: 3-8% concentration. Duration: 8-12 weeks for visible results, ongoing use.

Timing & Administration

Administer via Topical (serums, creams). Frequency: Applied twice daily.

Mechanism of Action

Lipopeptide that signals to fibroblasts to produce more collagen and other extracellular matrix proteins. The palmitoyl chain enhances skin penetration.

Research Summary

Evidence level: community reported. Clinical status: Cosmetic use - Extensively studied.

Side Effects & Safety

Important Warnings

  • Generally very well-tolerated
Redness (rare)
itching (rare)
minimal systemic absorption

References

No references available.

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