Peptipedia
Skin & HairNot FDA ApprovedCommunity Reported

Argireline

Also known as Acetyl Hexapeptide-3, Acetyl Hexapeptide-8

A popular cosmetic peptide that reduces facial wrinkles by inhibiting neurotransmitter release. Studies show 30% reduction in wrinkle depth after 30 days.

Cosmetic use - Widely available
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Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

5-10% concentration in formulations

Frequency

Twice daily

Duration

Ongoing use for maintained effects

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 5-10% concentration in formulations via Topical (serums, creams), Twice daily. Dose range: 5-10% concentration. Duration: Ongoing use for maintained effects.

Timing & Administration

Administer via Topical (serums, creams). Frequency: Twice daily.

Mechanism of Action

Mimics the N-terminal of SNAP-25 protein, inhibiting SNARE complex formation necessary for muscle contraction. Reduces facial muscle movement and subsequently wrinkle formation.

Research Summary

Evidence level: community reported. Clinical status: Cosmetic use - Widely available.

Side Effects & Safety

Important Warnings

  • Much fewer side effects than botulinum toxin
Mild skin irritation (rare)
redness or tingling (rare)

References

No references available.

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