Skin & HairNot FDA ApprovedCommunity Reported

SNAP-8

Also known as Acetyl Octapeptide-3, SNAP-8

A cosmetic peptide that reduces wrinkles by inhibiting muscle contraction. Studies show up to 63% reduction in wrinkle depth over 28 days.

Cosmetic use - Widely available in skincare

Regulatory Pathway

Preclinical
Phase I
Phase II
Phase III
Phase IV
Approved

Dosing Protocol

Typical Dose

3-10% in topical formulations

Frequency

Applied twice daily

Duration

Ongoing use for maintained effects

Community-reported dosing. Individual results vary. Not a medical recommendation.
Typical community protocol: 3-10% in topical formulations via Topical (serums, creams), Applied twice daily. Dose range: 3-10% concentration. Duration: Ongoing use for maintained effects.

Timing & Administration

Administer via Topical (serums, creams). Frequency: Applied twice daily.

Mechanism of Action

Fragment of SNAP-25 that interferes with SNARE complex formation needed for neurotransmitter release. Competes with native SNAP-25, reducing acetylcholine at the neuromuscular junction, decreasing muscle contraction.

Research Summary

Evidence level: community reported. Clinical status: Cosmetic use - Widely available in skincare.

Side Effects & Safety

Important Warnings

  • No systemic toxicity reported
Mild tingling (initial applications)
mild skin irritation (high concentrations)

References

No references available.